July 2024
Using Eukaryotic antiviral defense systems to predict antiphage activities in Pseudomonas. Amazing work by Daan, Rita and Jelger now published in CHM.
June 2024
Sam did an amazing job during his PhD and defended brilliantly. Congrats with your well deserved degree. We wish you all the best.
May 2024
The retreat to the Belgian coast was amazing.
February 2024
Work that was years in the making about the role of phage defense systems in pathogenic bacteria is now published. Awesome job Rita, Daan and Jelger!
May 2023
The group retreat in the Belgian Ardennes was too much fun
January 2023
Cristian defended his PhD thesis with great skill. What a superb day it was. We wish you all the best in the future.
November 2022
Amazing structure of a Jumbo phage infecting pathogenic bacteria. What a collaboration with Leiden University led by Ruochen Ouyang and Ariane Briegel.
October 2022
Massive NRM review on the amazing Type III and VI CRISPR-Cas systems, and how they act, sometimes at the cost of cell suicide. Great work by Sam and Alicia, with student Jasper.
September 2022
Marina publishes her review on methods to engineer a bacteriophage genome. Perfect timing for a those phage engineers. Great stuff.
May 2022
Becca's paper with Emma was published measuring individual CRISPR response of cells. So cool to see CRISPR in action in individual cells.
April 2022
Bel and Daan publish their work describing SPARTA pAgo systems in Cell. Great that we could contribute to such beautiful story.
March 2022
What a nice way to spend the day in the amusement park Efteling, after such a long time of COVID restrictions.
October 2021
Becca defending her PhD with class! What a nice day to conclude your journey in the Netherlands. All the best in New Zealand.
October 2021
Beautiful review by Julia and Rita on bacteriophage defense systems and their (unknown) clinical relevance. Thanks Pieter-Jan Haas MD (UMCU) for joining this effort.
October 2021
Together with the Ailong Ke lab at Cornell we publish a Cas4 paper in Nature, describing how this protein achieves PAM selection during CRISPR adaptation. What a result. Thanks Chunyi & Ailong, Cristobal, Rita, Jochem, Anna et al.
October 2021
Jochem becomes a bioinformatician during COVID with this paper: lessons for CRISPR spacer matching in metagenomic databases. 32% of the spacers match the database, 200 identified PAMs, PAM predictions from repeat nucleotides, evidence for spacer sharing.
September 2021
Jochem defending his PhD thesis as 'the master' of Microbiology and Biophysics. What a great achievement! All the best in New Zealand.
August 2021
Sam publishes the gRAMP paper in Science. Getting Caspase involved in CRISPR gives Craspase. What an awesome result and team effort.
August 2021
The amazing Rita and Boris publish four new phages we uncovered from wastewater, including a Jumbo phage. That one belong to a new genus named VanLeeuwenhoek viridae. How cool to uncover natural diversity.
August 2021
Kayaking in Delft's 'backcountry'
December 2020
Thank you EU ERC for funding our research into bacterial immune systems! Please see vacancies here.
Visiting address
Van der Maasweg 9, 2629 HZ Delft, Netherlands
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology
Applied Sciences Building (nr. 58) Office E1.480
My lab is interested in the interaction between microbes and bacteriophages. We study the mechanisms that bacteria use to protect themselves from infections including CRISPR and other phage defense systems, and we explore the adaptations that viruses have evolved to avoid defence systems. We isolate and engineer bacteriophages for phage therapy applications.
Address
Kavli Institute of Nanoscience
Delft University of Technology
Applied Sciences Building (nr. 58) Office E1.480
Van der Maasweg 9
2629 HZ Delft
Netherlands