Welcome to the Brouns lab

Microbe - Bacteriophage interactions

An adaptive immune system called CRISPR is an advanced weapon that microbes deploy in the war with viruses. This ingenious immune system has a memory and works by encoding small RNA molecules that target the destruction of virus DNA. Nowadays, CRISPR is well known for its revolutionary applications in genome editing with the enzyme Cas9 and Cas12. These enzymes allow changing DNA of any living species.


News

November 2017

Our TU Delft team won the grand prize and 8 individual prizes in the overgraduate section of the iGEM Jamboree in Boston. WOW I'm so proud! Superb job team! Thanks supervisors for making this possible. Read about their project and watch the award ceremony here.

October 2017

Big promo for Phage therapy in the Netherlands on ' Dokters van Morgen' by AVROTROS. A new website has been launched to promote phage therapy for patients in the Netherlands. At this site you can donate for Bacteriophage therapy research in the Netherlands.

October 2017

Luuk Loeff defended his PhD thesis and got a Cum laude. Committee members: Lucas van Vliet (Dean), Marileen Dogterom, Blake Wiedenheft, Euijeon Woo, Johannes Hohlbein, Cees Dekker (Promotor), Chirlmin Joo (Co-promotor).

October 2017

Tim got his PhD degree from Wageningen University. Congratulations on this superb job! Glad you were my PhD student.

Committee members: Joyce Lebbink, Blake Wiedenheft, Dolf Weijers, Chirlmin Joo, John van der Oost (promotor), paranimfs Marnix Vlot and Benoit Carreres.

August 2017

Franklin gets a VENI grant from NWO!

Phage killing bacteria
Phage killing bacteria

May 2017

This timelapse over 5 hours shows how antibiotic resistant E. coli bacteria are killed by phage. Perhaps one day the full potential of bacteriophages will be exploited for the treatment of infectious diseases in the Netherlands. Until then the Eliava Institute in Tblisi (Georgia) and the Queen Astrid Military Hospital in Brussels (Belgium) are one of the best places for phage therapy.

April 2017

Our review on how CRISPR systems generate memories of their invading viruses was published in Science. This was a great collaboration with the Fineran lab in New Zealand.

March 2017

The Nanofront winter retreat in Courchevel (France) was a great succes. Hardcore science and skiing turned out to be a good combination.

March 2017

Commented on the potential of phage therapy in Zorg.nu on Dutch national television. Other guests included Jesse Nederlof and Prof. Jan Kluytmans. 

Februari 2017

Franklin defended his thesis in front of a committee of Peter Fineran, Just Vlak, Rob Lavigne and Bertus Beaumont. Well done!

August 2016

Tim publishes a paper in Molecular Cell. Great stuff!

The paper describes that CRISPR systems cleverly couple target interference to CRISPR memory update. The Cas3 nuclease fragments invader DNA into pieces of near-spacer length enriched for PAM sequences on 30 ends to form spacer precursors.

Visiting address

Van der Maasweg 9, 2629 HZ Delft, Netherlands, T +31 15 2783920

Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology

Applied Sciences Building (nr. 58) Office E1.480,