Our TU Delft team won the grand prize and 8 individual prizes in the overgraduate section of the iGEM Jamboree in Boston. WOW I'm so proud! Superb job team! Thanks supervisors for making this possible. Read about their project and watch the award ceremony here.
Luuk Loeff defended his PhD thesis and got a Cum laude. Committee members: Lucas van Vliet (Dean), Marileen Dogterom, Blake Wiedenheft, Euijeon Woo, Johannes Hohlbein, Cees Dekker (Promotor), Chirlmin Joo (Co-promotor).
Tim got his PhD degree from Wageningen University. Congratulations on this superb job! Glad you were my PhD student.
Committee members: Joyce Lebbink, Blake Wiedenheft, Dolf Weijers, Chirlmin Joo, John van der Oost (promotor), paranimfs Marnix Vlot and Benoit Carreres.
Franklin gets a VENI grant from NWO!
This timelapse over 5 hours shows how antibiotic resistant E. coli bacteria are killed by phage. Perhaps one day the full potential of bacteriophages will be exploited for the treatment of infectious diseases in the Netherlands. Until then the Eliava Institute in Tblisi (Georgia) and the Queen Astrid Military Hospital in Brussels (Belgium) are one of the best places for phage therapy.
Our review on how CRISPR systems generate memories of their invading viruses was published in Science. This was a great collaboration with the Fineran lab in New Zealand.
The Nanofront winter retreat in Courchevel (France) was a great succes. Hardcore science and skiing turned out to be a good combination.
Commented on the potential of phage therapy in Zorg.nu on Dutch national television. Other guests included Jesse Nederlof and Prof. Jan Kluytmans.
Franklin defended his thesis in front of a committee of Peter Fineran, Just Vlak, Rob Lavigne and Bertus Beaumont. Well done!
Tim publishes a paper in Molecular Cell. Great stuff!
The paper describes that CRISPR systems cleverly couple target interference to CRISPR memory update. The Cas3 nuclease fragments invader DNA into pieces of near-spacer length enriched for PAM sequences on 30 ends to form spacer precursors.
Van der Maasweg 9, 2629 HZ Delft, Netherlands, T +31 15 2783920
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology
Applied Sciences Building (nr. 58) Office E1.480,
My lab is interested in the interaction between microbes and viruses. We study the mechanisms that bacteria and archaea use to protect themselves from virus infection including CRISPR, and explore the adaptations that viruses have evolved to avoid defence systems. We isolate and engineer bacteriophages for phage therapy applications.
Stan J.J. Brouns, PhD
Kavli Institute of Nanoscience
Applied Sciences Building (nr. 58) Office E1.480
Van der Maasweg 9
2629 HZ Delft
T +31 15 278 3920
HELIX Building (nr. 124)
6708 WE Wageningen
E. coli Cascade complex