Franklin and I made a timelapse over 5 hours of antibiotic resistant E. coli bacteria being killed by phage. Perhaps one day the full potential of bacteriophages will be exploited for the treatment of infectious diseases in the Netherlands. Until then the Eliava Institute in Georgia is the best place for phage therapy.
Our review on how CRISPR systems generate memories of their invading viruses was published in Science. This was a great collaboration with the Fineran lab in New Zealand.
Cristian joined as a PhD candidate. Welcome to the group!
The Nanofront winter retreat in Courchevel (France) was a great succes. Hardcore science and skiing turned out to be a good combination.
Commented on the potential of phage therapy in Zorg.nu on Dutch national television. Other guests included Jesse Nederlof and Prof. Jan Kluytmans.
100 years of Microbiology in Wageningen is celebrated with a symposium. Feel free to register
Franklin defended his thesis in front of a committee of Peter Fineran, Just Vlak, Rob Lavigne and Bertus Beaumont. Well done!
iGEM 2017 has started. The team consists of 13 enthusiastic and bright students. Go for it team!
Gave a talk at the Dutch Future Society in Amsterdam about the future of genome editing. What should have been a 30 minute presentation ended up being 1 hour and 30 minutes. Never had so many questions.
Lunchlecture for Nanobiology students. Good to see so many enthousiasts.
After a summer of ordering equipment the lab in Delft is now operational! Seb, Becca, Marre and Fiona are the first users.
Tim publishes a paper in Molecular Cell. Great stuff!
The paper describes that CRISPR systems cleverly couple target interference to CRISPR memory update. The Cas3 nuclease fragments invader DNA into pieces of near-spacer length enriched for PAM sequences on 30 ends to form spacer precursors.
A very cool animation on the impact and future of CRISPR tools
The laboratory of Microbiology has finally moved into the HELIX building on campus. A great place for interdisciplinary interactions between the chair groups.
Started working for Bionanoscience at TU Delft in their new Applied Sciences building. I am really looking forward to this. Anna Haagma joined as a technician to help setup the lab. Welcome!
The annual CRISPR meeting in Tel Aviv (Israel) was a great success. Thanks to the organizers Rotem Sorek, Udi Qimron, Uri Gophna and Mike Terns for hosting a great event.
Van der Maasweg 9, 2629 HZ Delft, Netherlands, T +31 15 2783920
Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology
Applied Sciences Building (nr. 58) Office E1.480,
My lab is interested in the interaction between microbes and viruses. We study the mechanisms that bacteria and archaea use to protect themselves from virus infection including CRISPR, and explore the adaptations that viruses have evolved to avoid defence systems. We isolate and engineer bacteriophages for phage therapy applications.
Stan J.J. Brouns, PhD
Kavli Institute of Nanoscience
Applied Sciences Building (nr. 58) Office E1.480
Van der Maasweg 9
2629 HZ Delft
T +31 15 2783920
HELIX Building (nr. 124)
6708 WE Wageningen
T +31 317 483740
E. coli Cascade complex